TGM1 deficiency impairs CE formation (ARCI1, Table 2), TGM5 deficiency causes premature desquamation (peeling skin syndrome 2 (OMIM # 609796)), and TGM3 deficiency impairs hair shaft formation (uncombable hair syndrome 2 (OMIM # 617251)) [43]. The gene discussed is TGM1; the disease is uncombable hair syndrome 2.