Recently, the results of a phase III trial (IMbrave 150) evaluating the anti-PD-L1 mAb atezolizumab + bevacizumab versus sorafenib monotherapy for patients with unresectable HCC without prior systemic therapy were presented at ESMO Asia Congress 2019, revealing that the atezolizumab + bevacizumab combination significantly improved OS and PFS compared to sorafenib [42]. The gene discussed is CD274; the disease is hepatocellular carcinoma.