Finally, Hughes et al. demonstrated that CML patients in major molecular response (MMR) have an increase of CD56+CD94/NKG2C+NKG2D+NCR+KIR+ NK cells as compared to diagnosis, consistent with the restoration of a PB-NK cell repertoire typical of healthy individuals. This evidence concerns the gene NCAM1 and chronic myelogenous leukemia, BCR-ABL1 positive.