FLT3 and acute myeloid leukemia: FLT3-activating mutations occur in approximately 30% of patients with acute myeloid leukemia (AML) and, as such, are among the most frequent mutations found in AML [2], either as in-frame internal tandem duplications (ITD) within the juxtamembrane region or as missense point mutations in the tyrosine kinase domain (TKD) [3,4].