Furthermore, we confirmed the good diagnostic value of CSF ubiquitin in the differential diagnosis between prion disease and other NDs [4], and, most interestingly, between AD and FTD (AUC = 0.880, sensitivity = 86.8%, specificity = 80.0%), although, overall, the ubiquitin performance remained lower than that of classic biomarkers of neurodegeneration such as NfL and t-tau. This evidence concerns the gene NEFL and prion disease.