METTL3 and posterior cortical atrophy: Inspection of the genomic regions encoding each one of the MTC subunits revealed that VIRMA is the most commonly altered MTC protein in PCa (8% of the samples), whereas the other MTC subunits disclose lower frequencies of alterations (1% for METTL3, 3% for METTL14, and 1.8% for WTAP) (Figure 1A).