The expression of ADAM-10 was significantly increased in subpopulations of CD9-positive exosomes, from plasma and total blood of luminal subtype BCPs, when compared with HF (the difference was 1.8 and 1.3 fold, respectively), and triple-negative subtype BCP samples (the difference was 1.6 and 1.2 fold, respectively). The gene discussed is CD9; the disease is hydrops fetalis.