Furthermore, if neuron-microglia communication is impaired by interfering with the fractalkine receptor (CX3C chemokine receptor 1, Cx3cr1) in microglia, this would aggravate RGC loss in disease models such the ischemia-reperfusion [247] and glaucoma DBA/2J mouse [248], with no alterations in uninjured retinas [247]. Here, CX3CR1 is linked to glaucoma.