Interestingly, the authors stated specifically the finding of naked MKC, and suggested a clear difference in prognosis between cytoplasmic and naked MKC Bhakdi et al. [34] included the presence of “giant” polyploid CD45 negative cells into an extended CRC panel, that in combination was used as criterion to predict metastatic prostate cancer. The gene discussed is PTPRC; the disease is metastatic prostate carcinoma.