PTH1R and primary failure of tooth eruption: However, analyses have focused on patients with PFE and not on patients with other primary retention alterations, and these patients were divided into two groups: 11 subjects with a genetically-confirmed PFE (PTHR1 mutations) presenting with skeletal class III in 63.7% of the cases, and 47 subjects with clinically-diagnosed PFE that presented with skeletal class III in only in 23.4% of the cases.