Additionally, the CARDAPAC (Physical Activity Intervention on Myocardial Function in Patients with HER2 + Breast Cancer) (NCT02433067) study is exploring the impact of individualized exercise interventions (45 min, 3 days a week) in breast cancer patients treated with trastuzumab on LVEF, body composition, muscle function, metabolic, hormonal and inflammatory responses, pain, fatigue, and quality of life. This evidence concerns the gene ERBB2 and breast carcinoma.