Ex vivo restimulation of splenocytes with growth-arrested tumor cells demonstrated a significant enhancement of tumor-specific IFNγ production up to 2 weeks after mice were treated with a single dose of VVΔTKΔN1L (figure 2A), an effect also evident when splenocytes were restimulated ex vivo with a peptide representing the mesothelin epitope, overexpressed in pancreatic cancer (figure 2B). The gene discussed is IFNG; the disease is familial pancreatic carcinoma.