For instance, loss of mitochondrial transcription factor B1 (TFB1M), which catalyses m62A methylation of A936 and A937 in 12S rRNA, has been linked to type 2 diabetes and mitochondrial-associated deafness, presumably because the modifications regulate the translational efficiency of the mito-ribosome (for a full review, see [112]). This evidence concerns the gene TFB1M and deafness.