PLAT and ST Elevation Myocardial Infarction: Two multicenter, international trials are scheduled to investigate the efficacy of reduced doses of either alteplase (STRIVE [Adjunctive, Low-dose tPA in Primary PCI for STEMI]; NCT03335839) or tenecteplase (RESTORE-MI [Restoring Microcirculatory Perfusion in ST-Elevation Myocardial Infarction (STEMI)]; ACTRN12618000778280) (Supplemental Appendix).