In LOPE, maternal factors such as obesity, hyperlipidemia, diabetes andchronic hypertension highly contribute to the emergence of the disease [42–45] In our experiment the high expression of PPAR-γ induced by treatment with serum of LOPE may indicate PPAR-γ expression is inversely correlates with its activity. Here, PPARG is linked to obesity due to melanocortin 4 receptor deficiency.