In a previous study that compared JEG-3 cell lines treated with serum extract either from women with normal pregnancy, mild, severe early-onset, or severe late-onset preeclampsia, Waite et al. demonstrated that PPARγ activators was reduced by 60% in the sera of severe early onset and by 55% in severe late onset preeclampsia compared to that of normal serum [22]. This evidence concerns the gene PPARG and preeclampsia.