TNF and osteoporosis: Because of the strong evidence for co-localisation of eBMD GWAS and osteoclast eQTL association signals within this locus, combined with the known role of RIPK3 in cellular necroptosis in response to the tumour necrosis factor (TNF)-alpha family of death-inducing cytokines and potential involvement in bone resorption in osteoporosis [26], we performed in-depth skeletal phenotyping of Ripk3-deficient mice.