Besides LP, other neuropathological hallmarks in clinically-defined PD donors included PSP tau pathology (n = 8, 5%), GCIs indicating a neuropathological diagnosis of MSA (n = 7, 4%), vascular lesions in nigrostriatal regions or features of small vessel disease in periventricular areas (n = 6, 3%), no neuropathological lesions (n = 2, 1%), AD-type pathology (n = 2, 1%) and a rare tauopathy (n = 1, 1%) (Figs. 1 and 2). Here, MAPT is linked to Alzheimer disease.