We also found that down-regulation of LTBP1 was accompanied by decreased expression of TGFβ, N-cadherin and vimentin, as well as increased expression of E-cadherin in ESCC cells, suggesting that LTBP1 may involve in regulating the secretion and activation of TGFβ and play an important role in promoting EMT in ESCC cells. The gene discussed is LTBP1; the disease is esophageal squamous cell carcinoma.