Mechanistically, HNF4A promotes the expression of glycolytic genes HK2 and SLC2A1, while HNF4A-AS1 binds to hnRNPU protein to facilitate its interaction with CTCF, resulting in transactivation of CTCF and transcriptional alteration of HNF4A and other genes associated with tumor progression. This evidence concerns the gene HK2 and neoplasm.