HNF4A-AS1 promotes aerobic glycolysis, growth, and aggressiveness of NB cells by binding to heterogeneous nuclear ribonucleoprotein U (hnRNPU) and facilitating its interaction with CCCTC-binding factor (CTCF), resulting in transactivation of CTCF and transcriptional alteration of HNF4A and other genes associated with tumor progression, indicating the crucial roles of HNF4A-AS1/hnRNPU/CTCF axis in NB progression. The gene discussed is HNRNPU; the disease is neuroblastoma.