In a public NB dataset (GSE45547), higher levels of HNF4A (P = 1.2 × 10−5), HK2 (P = 1.6 × 10−20), and SLC2A1 (P = 1.7 × 10−2) were noted in tumor tissues with advanced stages (Additional file 1: Figure S1i). This evidence concerns the gene HK2 and neuroblastoma.