We demonstrate that as a MYCN-facilitated lncRNA, HNF4A-AS1 interacts with hnRNPU protein to facilitate transactivation of CTCF, which epigenetically regulates transcription of HNF4A and other genes associated with tumor progression in cis and in trans (Fig. 6e), such as CLU [32], CXCR4 [33], TPBG [34], and UACA [35]. The gene discussed is CTCF; the disease is neoplasm.