RBPs have gained recent attention because, on the one hand, their aggregation can drive the formation of these functional membraneless RNP bodies, yet on the other hand, mutations in their low-complexity sequences are causal factors in neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and multisystem proteinopathy (MSP) [145]. Here, RNPC3 is linked to amyotrophic lateral sclerosis.