In MDS, loss‐of‐function mutations were found in the ASXL1 gene by aCGH analysis.17 These are typically nonsense or frame‐shift mutations in heterozygosis in the last exon of the gene, which truncate the protein before the C‐terminal PHD domain, resulting in a haploinsufficiency or a dominant negative effect. Here, ASXL1 is linked to myelodysplastic syndrome.