Although this last association had been reported in some AML ASXL1+ series,24, 28, 29 other publications, focused on patients with AML‐MRC, had shown contradictory results.15, 16 In MDS and CMML the presence of ASXL1 mutations have been associated with shorter transformation time to AML,19, 20 which could partly support the association of this mutation with a history of MDS and MDS‐MPN. This evidence concerns the gene ASXL1 and myelodysplastic syndrome.