They can occur simultaneously with RUNX1 and FLT3 mutations but have not been described together with NPM1 mutations.16 Previously, association of ASXL1 to AML‐MRC has been described.16, 25 In this work, 61 cases of AML‐MRC defined according to WHO 2017 criteria are studied along with 46 controls diagnosed with AML‐NOS. This evidence concerns the gene RUNX1 and acute myeloid leukemia.