For example, lncRNA CASC15‐S (cancer susceptibility 15) was found to be a tumor suppressor in NB by mediating neural growth and differentiation20; lncRNA pancTts‐1 promotes NB progression through hnRNPK‐mediated β‐catenin stabilization24; lncRNA lncNB1 promotes tumorigenesis of NB by interacting with ribosomal protein RPL35, and then, enhance E2F1 protein synthesis32; our previous studies also showed that lncRNA MYCNOS (MYCN opposite strand) cooperates with transfactor CTCF to promote NB progression through facilitating MYCN gene expression.32 This evidence concerns the gene CTCF and neuroblastoma.