For example, lncRNA CASC15‐S (cancer susceptibility 15) was found to be a tumor suppressor in NB by mediating neural growth and differentiation20; lncRNA pancTts‐1 promotes NB progression through hnRNPK‐mediated β‐catenin stabilization24; lncRNA lncNB1 promotes tumorigenesis of NB by interacting with ribosomal protein RPL35, and then, enhance E2F1 protein synthesis32; our previous studies also showed that lncRNA MYCNOS (MYCN opposite strand) cooperates with transfactor CTCF to promote NB progression through facilitating MYCN gene expression.32 The gene discussed is E2F1; the disease is cancer.