MCs beyond their role in allergic reactions are involved in a variety of physiologic processes including angiogenesis (by releasing FGF, vascular endothelial growth factor (VEGF), and TGF-β) [19] and wound healing (through releasing IL-4, VEGF, and basic fibroblast growth factor (bFGF) [14]. This evidence concerns the gene FGF2 and allergic disease.