FOLH1 and neoplasm: Our finding that total consolidation of disease detectable by PSMA-targeted PET-CT was associated with lower risk of new metastases at 6 months is consistent with this latter explanation, as is the recent overall survival improvement observed in the SABR-COMET trial.7 A deeper understanding of this process may be obtained through sequencing of biopsy or liquid biopsy specimens to explore the relationships and lineages of specific metastases in these patients14,26 or through advances in analysis of circulating readouts, such as circulating tumor cells, ctDNA, and exosomes.