In this analysis, the authors did not find any statistical significance regarding this polymorphism and CAD.20 Similarly, Brazilian authors analyzed 200 patients with acute coronary syndrome and their association with the presence of the IL6 -174 G > C polymorphism in Pernambuco, Brazil, and found no significant association between the presence of the risk alleles and acute coronary syndrome.27 Here, IL6 is linked to acute coronary syndrome.