We observed a strong association (p = 0.001) between the presence of the PCR + 1444 C > T polymorphism, risk allele T and the case group with OR = 6.37; (95%) 2.25 - 17.9, which contradicts authors who analyzed five studies, totaling 18,637 participants, where the PCR + 1444 C > T polymorphism was adjusted for confounding factors and compared regarding the presence of CAD, but found no association between this polymorphism and coronary disease.24 It is possible to infer that this association may arise from CRP serum levels maintained by chronic periodontitis over several years. Here, CRP is linked to periodontitis.