The HFSS,21 Sodium,22 NT-proBNP,23-25 right ventricular dysfunction,18 lower LVEF,19,20 CPET duration, HHR1,26 and initial and maximal SBP during CPET27 were included in this group, with all of them being formerly described as prognostic markers in HF patients. The gene discussed is NPPB; the disease is hydrops fetalis.