In addition, it has been shown that some inflammatory regulators such as NF-κB activation and inflammatory cytokines production have a positive stimulatory role in PC associated properties such as proliferation and metastasis, thus inhibited activity of these inflammatory pathways by α7nAChR-based pathways may represent a promising anti-cancer approach in PC therapy [98, 99]. The gene discussed is NFKB1; the disease is pachyonychia congenita.