GCG and type 2 diabetes mellitus: Although nine types of Kampo medicines, Rokumigan, Hachimijiogan, Goshajinkigan, Ninjinyoueito, Juzentaihoto, Sokeikakketsuto, Byakkokaninjinto, Keishibukuryogan, and Keishikajutsubuto, are prescribed to ameliorate the symptoms of T2DM, their effects on the glucagon signaling pathway have not yet been investigated.