INS and diabetes mellitus: On the other hand, the administration of Keishikajutsubuto resulted in improvements in impaired insulin effects in STZ-diabetes rats, and the administration of Keishibukuryogan produced significanUt improvements against impaired glucose tolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of T2DM, suggesting that Keishikajutsubuto and Keishibukuryogan exert beneficial effects on the symptoms of T2DM [29, 30].