Mice bearing either PTEN-deficient BP xenografts or PTEN-WT colon carcinoma CT26 xenografts were treated with vehicle, AZD8186 (50 mg/kg daily), anti-PD1 (200 μg, twice a week), paclitaxel (10 mg/kg, once a week), or various combinations between these agents as indicated in Figure 6C. The gene discussed is PTEN; the disease is colon carcinoma.