Moreover, we found that either HIF-1α or Annexin A1 knockdown significantly inhibited hypoxia-induced cell migration and invasion of androgen-independent prostate cancer cells, suggesting that HIF-1α/Annexin A1 signaling regulated by TRPM7 plays an essential role in the metastasis of prostate cancer under hypoxic condition. The gene discussed is HIF1A; the disease is Familial prostate cancer.