Our study is consistent with these findings, also showed that knockdown of both TRPM7 and HIF-1α inhibited EMT changes of androgen-independent prostate cancer cells induced by hypoxia, suggesting that TRPM7 regulates HIF-1α-mediated signaling to affect hypoxia-induced EMT in androgen-independent prostate cancer cells. The gene discussed is TRPM7; the disease is prostate carcinoma.