Silencing PGC-1α in skeletal muscle drastically downregulates superoxide dismutase 1 (SOD1) expression, increases oxidative stress, causes energy deficiency, augments the serum levels of proinflammatory cytokines, and induces muscle fibrosis, the major pathological feature of amyotrophic lateral sclerosis [151]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.