Also, acupuncture therapies were reported as being capable of decreasing secretion of IL-6 [21, 39, 69, 72, 74, 77], high mobility group protein box-1 (HMGB1) [66, 67, 69, 76, 81], TNF-α [21, 30, 31, 34, 35, 38–41, 46, 48, 50, 63, 66–71, 74, 76, 77], IL-10 [30, 31, 38, 46, 48, 50, 63, 68], and interferon-γ (IFN-γ) [71], demonstrating acupuncture at ST36's potential of reducing inflammation in sepsis. Here, HMGB1 is linked to Sepsis.