Interestingly, in our study, we found that FD rats were followed by gastric motility disfunction and also followed by increased hippocampal glutamate and the upregulated NMDAR-NO-cGMP pathway, however, when microinjection of the NMDAR, nNOS, or sGC inhibitor into the hippocampus could restore the gastric motility of FD rats. Here, NOS1 is linked to Fabry disease.