At the same time, the effect of isoimperatorin on nasopharyngeal carcinoma cells apoptosis was also reduced, that is, the MAPK/ERK activator dampened the ability of isoimperatorin to induce apoptosis, indicating that isoimperatorin may prevent nasopharyngeal carcinoma proliferation and induce apoptosis via the MAPK/ERK1/2 signaling pathway. Here, MAPK3 is linked to nasopharyngeal carcinoma.