IP6K2 and lung cancer: using in vitro and in vivo approaches.107, 108 The Snyder group showed that gene deletion of Ip6k2 in HCT116 human colorectal cancer cells and Ip6k2 knockdown in breast and lung cancer cell lines led to a reduction in focal adhesion kinase (FAK) phosphorylation, correlating with reduced cell spreading and cell–matrix adhesion.107 Epithelial to mesenchymal transition properties including cell migration and invasion were also significantly reduced in these cells.