EDNRA and obesity due to melanocortin 4 receptor deficiency: To further evaluate the significant interactions identified above, we estimated the adjusted mean differences in fibrinogen and the adjusted mean ratios in carotid IMT and hs-CRP level for CRP, FGA, PON1, and EDNRA minor-minor genotype in comparison with minor-major/major-major genotype stratified by gender (Fig 1) and obesity (Fig 2).