CRP and obesity due to melanocortin 4 receptor deficiency: For gene-obesity interaction, obese individuals carrying the minor-minor genotype of CRP SNP rs1130864 and rs3093059 had a significantly lower adjusted mean IMT value than those carrying minor-major/major-major genotype (0.70 [0.64, 0.76] and 0.64 [0.56, 0.75], respectively) (Fig 2A and S1 Table).