Since Hashimoto et al. first demonstrated that the preoperative serum CRP level is an independent and significant factor predictive of a poor prognosis in patients undergoing surgical resection, several investigators have identified an elevated serum CRP level to be an indicator of poor outcomes in HCC patients undergoing transplantation, TACE and radiofrequency ablation[47–51]. The gene discussed is CRP; the disease is hepatocellular carcinoma.