In our study, the results showed that PCC0208025 not only increased the IFN-γ level in plasma, but also increased the number of CD8+IFN-γ+ T cells in tumors in B16-F10 melanoma-bearing mice, which either induce immune cells proliferation and differentiation or produce direct tumor-killing effects to inhibit tumor growth [24]. Here, CD8A is linked to melanoma.