We and others have shown earlier [12, 13, 14] that mutations of ACP5 can cause autoimmune cytopenia, immuno-osseous dysplasia, spasticity with leukodystrophy, systemic lupus erythematosus (SLE), Moyamoya syndrome and Sjogren’s syndrome [15–17]. This evidence concerns the gene ACP5 and systemic lupus erythematosus.