Functions of C/EBPα can be inhibited by BCR-ABL-induced upregulation of hRNP-E2 with associated C/EBPα mRNA instability in CML and inhibition of C/EBPα dimerization by FLT3-ITD-induced phosphorylation in AML. This evidence concerns the gene ABL1 and chronic myelogenous leukemia, BCR-ABL1 positive.