Finally, all C/EBPα and -β isoforms and full-length C/EBPε were overexpressed in Ba/F3 FLT3-wt, Ba/F3 FLT3-ITD 598/599(22)-AML cells, and AR230 CML cells, which were co-transfected with a C/EBP1/2 binding-site containing SIRT7-promoter-luciferase reporter-gene plasmid. Here, HERC5 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.