DLC1 and neoplasm: Consistent with its tumor-suppressor function, deep (6.9%) and shallow (61.5%) deletion of the DLC1 gene were more frequently detected in human hepatocellular carcinoma than that of melanoma (deep, 0.28%; shallow, 22.9%) that correlated with lower DLC1 mRNA expression levels among liver tumor samples (Fig. 1a, b) [26].