ARHGAP1 and melanoma: Besides, OE of RhoGAP deficient mutant (K714E), which was shown to abolish the suppressive function of DLC1 in liver cancer [22], exhibited a similar oncogenic activity to WT-DLC1 in promoting melanoma growth and invasion, further supporting the notion that DLC1 functions in a RhoGAP-independent manner to orchestrate the oncogenic events.