Hence, differential responses to DLC1 OE in melanoma cell lines expressing distinct levels of endogenous DLC1 could be due to the limited amount of FOXK1 available to translocate exogenous DLC1 into the nucleus of DLC1HIGH cells, whereas FOXK1 is still in excess to promote nuclear translocation of ectopic DLC1 in DLC1LOW cells. This evidence concerns the gene DLC1 and melanoma.