We found a highly correlated expression between DLC1 and FOXK1 in the majority of metastatic melanomas (39/50, 78%; p < 0.0001), in which the levels of nuclear DLC1 exhibited positive correlation with MMP9 expression (18/39, 46.2% with strong expression in both DLC1/MMP9; 10/39, 25.6% with weak expression in both DLC1/MMP9; p = 0.0154) (Fig. 6a–c). This evidence concerns the gene FOXK1 and melanoma.