Over 50% of melanoma patients harbor the BRAF mutation, which leads to constitutive activation of the oncogenic signaling pathways together with dysregulated expression of cancer driver genes, resulting in the neoplastic transformation of embryonic neural crest (NC)-derived melanocytes located in the basal layer of the skin epidermis into metastatic melanomas [2, 3]. Here, BRAF is linked to metastatic melanoma.