DLC1 and neoplasm: By immunostaining, we detected an increase in the number of tumor cells expressing nuclear DLC1 on cross sections of lung nodules treated with FOXK1 OE compared with control, whereas DLC1 was barely observed in the nucleus of FOXK1 KD cells (Fig. 4g, h), further consolidating our in vitro observations that FOXK1 is sufficient and required for nuclear translocation and retention of DLC1, respectively.