In addition, multimarker haplotype analysis showed that 4 of the 2 haplotypes (rs3025039-rs3025040-rs10434: GGA and GTA) within the EDN1 gene region were significantly different between soldiers with AMS and those without AMS (Globe λ test, χ2 = 11.85, P = 0.008, Table 3). The gene discussed is EDN1; the disease is ablepharon macrostomia syndrome.