With our prioritization analysis, we identify the oral lichen planus interactome, consisting of two clusters of 21 proteins: CXCL10, CXCL12, CCL5 (RANTES), CCL19, CCL20, CCL21, CXCR1, CXCR2, CXCR3, CXCR4, CCR1, CCR2, CCR3, CCR5, CCR6, CCR7, IL-8, MTHFR, MTR, MTRR, and MTHFD1. Here, MTHFR is linked to lichen planus.