Mutations in the aryl hydrocarbon receptor-interacting protein-like 1 (AIPL1) gene lead to early onset retinal disease and account for up to 5–10% of all mutations causing LCA3 resulting in a clinically severe form, LCA type 4 (LCA4, OMIM #604393)4. The gene discussed is AIPL1; the disease is Abnormal retinal morphology.