To characterize the phenotype associated with METN375S in SCC, we generated isogenic cell lines expressing either wild-type or variant MET with turboGFP tag (tGFP) (METwt-tGFP and METN375S-tGFP) in two LUSC lines (the epithelial H2170 cells and the p53-null mesenchymal Calu-1 cells) and two HNSCC lines (the cutaneous SCC13 cells and oral SCC UMSCC-1 cells). Here, TP53 is linked to head and neck squamous cell carcinoma.