In case of FOXO1 known as a putative tumor suppressor, phosphorylation of FOXO1 by CDK1 inhibits the transcriptional activity of FOXO1 and promotes cell proliferation61 while CDK1 phosphorylation of FOXO1 stimulates FOXO1-dependent transcription and leads to cell death in neurons62. Here, FOXO1 is linked to neoplasm.