HFE and pachyonychia congenita: A similar association has been observed also for pancreatic cancer [55], as HFE rs1799945 (i.e., H63D) was significantly associated with PC risk, with each additional copy of minor allele T being associated with a 1.21-fold increased risk of PC (OR = 1.21, 95 % CI = 1.05–1.39, P = 7.72 × 10−3) in Chinese population including 1000 cases and as many controls.