MYC and cancer: The specific roles of PVT1 in cancer are still not clearly understood; however, it has been demonstrated to promote cell proliferation and the acquisition of stem cell-like properties in HCC cells by stabilizing NOP2 (nucleolar protein 2) [151] or, in other tumors, by downregulating the transcription of MYC (Myc proto-oncogene protein), its upstream neighboring gene [153].