MEG3 and neoplasm: In fact, several lncRNAs such as HOTAIR (homebox C transcript antisense RNA) or PVT1 (lncRNA plasmacytoma variant translocation 1) behave as oncogenes [56,57], whereas others such as MEG3 (maternally expressed 3) or PANDAR (promoter of CDKN1A antisense DNA damage-activated RNA) act as tumor suppressors [58,59].