First we investigated the prevalence of genotypes in MECP2: rs2075596 G/A, rs1734787 C/A, rs17435 A/T, rs2239464 G/A, and CCR5 rs333 genes in SLE patients and healthy controls to find out if there is an association with specific genotype and/or allele and the occurrence of the SLE disease. This evidence concerns the gene MECP2 and systemic lupus erythematosus.