Because MECP2 polymorphisms revealed an association in the pooled analysis of Polish subjects, and because of we hypothesize that MECP2 gene and/or CCR5 gene may be good candidate genes to play a part in SLE pathogenesis, we decided to carry on analysis whether genetic variants located in these genes may have an impact on SLE phenotype. This evidence concerns the gene CCR5 and systemic lupus erythematosus.