Among those is the ER stress-related protein calreticulin, which regulates adipogenesis, and it was shown to be increased in IR and obesity [45] or S100A6 that belongs to a large family of Ca2+ binding proteins implicated in numerous human diseases, such as rheumatoid disease, acute inflammatory lesions, cardiomyopathies, and cancer [46]. The gene discussed is CALR; the disease is obesity due to melanocortin 4 receptor deficiency.